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KMID : 1134820150440040506
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 4 p.506 ~ p.515
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Pomegranate Extract Improves Menopausal Syndrome in Ovariectomized Rats
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Wee Ji-Hyang
Jung Hyun-Jung
Jung Kyung-Ok
Sung Hea-Mi
Shin Yu-Rim
Park Ju-Hyun
Seo Hyeon-Young
Lim Jung-Min
Chae Han-Jung
Lee Ki-Yung
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Abstract
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In this study, the effect of Goheung pomegranate extract on postmenopausal syndrome was evaluated both in vitro and in vivo in ovariectomized Sprague-Dawly (SD) rats. Sixty female SD rats were divided into six groups: sham, sham operation and distilled water; OVX, ovariectomized and distilled water; PE1, ovariectomized and pomegranate concentrate (0.75 mL/twice/d); PE2, ovariectomized and pomegranate concentrate (1.5 mL/twice/d); PE3, ovariectomized and pomegranate concentrate (2.2 mL/twice/d); and CE, ovariectomized and commercial pomegranate concentrate (2.2 mL/twice/d). Percent bone volume (bone volume/tissue volume) and trabecular thickness (Tb.Th) improved in a dose-independent manner in PE1, 2, and 3. Especially, bone mineral density was significantly improved in PE3 (P<0.05) compared to OVX. Pomegranate extract reduced body weight and visceral fat mass. High density lipoprotein cholesterol (HDL-C) level slightly increased in a dose-independent manner in the experimental group. In addition, HDL-C/total cholesterol level of PE3 significantly increased (P<0.05) compared with OVX. These results show that pomegranate concentrate improved blood lipid levels and bone metabolism in ovariectomized rats. Therefore, Goheung pomegranate concentrates are expected to improve cardiovascular and bone-related diseases in menopausal women.
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KEYWORD
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pomegranate, female menopausal symptom, ellagic acid, serum lipid, bone mineral density
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